Indeed, beyond a simple blood gas analysis with basic chemistry and hematology, measurements such as renal, cardiac or inflammatory biomarkers and coagulation tests are now available. Thanks to advances in technologies and the miniaturization of electronic devices, just in minutes, novel POC analyzers are now able to measure a large number of parameters from a small blood sample. In the last decades, POC testing applications have increased, especially in Emergency Departments (EDs) and Intensive Care Units (ICUs), where rapid diagnosis and treatment are a cornerstone of patient care. POC testing results are available rapidly, helping physicians in diagnosis and the prompt initiation and monitoring of therapeutic interventions. Point-of-Care (POC) testing is defined as testing performed near or at a patient’s bedside instead of in a conventional central laboratory. However, clinicians should interpret Po 2, creatinine and PT results with caution. The i-STAT Alinity appeared as a convenient device for measurements of numerous parameters. However, correlations of the PT and INR measurements with existing instruments were lower (R 2 = 86.0% and 89.7%), and biases in the Po 2 (7.9%), creatinine (5.4%) and PT (−6.6%) measurements were higher. We found that the within-lab coefficients of variation (CV) were very low ( 95%) correlated with those of the existing laboratory instruments, and the biases were very low (<2%) or low (2–5%). We assessed the imprecision and compared the results to those obtained on existing instruments in the central laboratory. We conducted an analytical performances study with the i-STAT Alinity device using cartridges CG4+ (pH, Pco 2, Po 2, lactate, bicarbonate and base excess) CHEM8+ (Na, K, Cl, ionized Ca, urea, creatinine, glucose, hematocrit and hemoglobin) and PT/INR (prothrombin time and international normalized ratio).

Herein, we aimed to assess the analytical performances of the i-STAT Alinity system. However, data regarding their analytical performances in real-world situations remains scarce. Many Point-of-Care devices have been released over the past decade.

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